Often used to treat high cardiovascular issues, oral Spironolactone also has the unique ability to block oil gland production. While not FDA-approved for acne (it treats the skin off-label), this is a great option for those who don't want to take Accutane. One of the side effects of Spironolactone is increased urination. The medication also retains potassium, so you shouldn't eat foods that are rich in that mineral. As Dr. Schultz says, "You can't go bananas over bananas if you are taking Spironolactone." This can be a precursor to Accutane — if you don't see results on Spironolactone, your doctor might give you a vitamin A derivative.