They're with other people now, but when Sarah Silverman and Jimmy Kimmel dated for several years in the mid-2000s, they were the ultimate comedy power couple. The late-night host even got worked into the stand-up comedian's bits, like in this famous joke about their different religions: "I wear this St. Christopher medal sometimes because — I’m Jewish, but my boyfriend is Catholic — it was cute the way he gave it to me. He said if it doesn’t burn through my skin it will protect me.”