"Off I Go" by Greg Laswell
- When it destroyed you: Season five, episode 24
- Why it destroyed you: As Izzie crashes and Cristina and Alex fight over whether or not to revive her, Meredith tearfully discovers that John Doe is George just before he dies. Just to make sure your heart is 100 percent in pieces, there's a trademark Meredith Grey voice-over to seal the deal: "Did you say it? 'I love you, I don't ever want to live without you. You changed my life.' Did you say it?"