Popsugar Lifestyle Slang What Does Bless Up Mean? Your Definitive Guide to Understand What Bless Up Actually Means 3 February, 2016 by Ann-Marie Alcántara View On One Page Photo 1 of 9 ADVERTISEMENT () Start Slideshow Share This Link Copy ← Use Arrow Keys → 1 First, this is how DJ Khaled uses it. Previous Next Start Slideshow SlangMemesGeek HumorDigital Life